An investigation of possible transynaptic neuronal degeneration in human spinal cord injury

Neurophysiological studies suggested that transynaptic neuronal degeneration of the anterior horn cells (AHC) may occur after an upper motoneuron lesion as the result of "deafferentation". To test this observation anatomically, patients with spinal cord injury (SCI) who had come to post mortem were investigated. Four patients with longstanding clinically and pathologically "complete" SCI were selected for comparison with 4 age-matched normal controls and with 2 patients who died of motoneuron disease (MND). The total number of AHCs in the L3 spinal cord segment was counted in each of the cases. The lesions in the traumatic group were all above the L3 segment. No significant differences in the number of AHC between the test cases and the normal controls was found. There was, as expected, a highly significant difference between the test cases and those with MND. The conclusion drawn from the study is that transynaptic neuronal degeneration of AHCs does not occur following complete transection of the human spinal cord. Thus the neurophysiological hypothesis is not supported anatomically.