Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Specific IgG subclass reactivity in herpes simplex encephalitis.

T Mathiesen1, A Linde, E Olding-Stenkvist

  • 1Department of Virology, National Bacteriological Laboratory, Stockholm, Sweden.

Journal of Neurology
|September 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Timing of umbilical cord occlusion, delayed vs early, in preterm babies: A randomized controlled trial (CODE-P Trial).

European journal of obstetrics, gynecology, and reproductive biology·2023
Same author

Cardiomyopathy Across the Tree of Life: Insights for Clinicians and Investigators.

Circulation. Heart failure·2023
Same author

Natural History of Innate Host Defense Peptides.

Probiotics and antimicrobial proteins·2016
Same author

Self-sampling for analysis of respiratory viruses in a large-scale epidemiological study in Sweden.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2015
Same author

[SK2 guidelines for assessment of mental and psychosomatic diseases: A statement].

Der Nervenarzt·2013
Same author

Prevailing effectiveness of the 2009 influenza A(H1N1)pdm09 vaccine during the 2010/11 season in Sweden.

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin·2013
Same journal

Movement disorders in GLUT1 deficiency syndrome: a systematic review of the literature.

Journal of neurology·2026
Same journal

Detailed clinical characteristics of musical hallucinations in 81 patients.

Journal of neurology·2026
Same journal

The dual role of mTOR in multiple sclerosis pathophysiology: a systematic review.

Journal of neurology·2026
Same journal

Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.

Journal of neurology·2026
Same journal

Spontaneous intracranial hypotension due to pelvic cerebrospinal fluid leak.

Journal of neurology·2026
Same journal

Morbidity and medication use preceding a diagnosis of late-onset Alzheimer's disease: a Danish nationwide study.

Journal of neurology·2026
See all related articles

Herpes simplex virus encephalitis (HSVE) diagnosis can be challenging. Detecting specific IgG subclasses in cerebrospinal fluid (CSF) aids in identifying HSVE, distinguishing it from other infections.

Area of Science:

  • Neurovirology
  • Immunology
  • Infectious Diseases

Background:

  • Herpes simplex virus encephalitis (HSVE) diagnosis relies on clinical presentation and laboratory tests.
  • Distinguishing HSVE from other forms of encephalitis is crucial for appropriate treatment.
  • Immunoglobulin G (IgG) subclass analysis may offer insights into viral infections and immune responses.

Purpose of the Study:

  • To investigate the utility of detecting IgG subclasses reactive to herpes simplex virus (HSV), cytomegalovirus (CMV), and varicella zoster virus (VZV) in serum and CSF.
  • To differentiate HSVE from non-HSVE encephalitis and healthy controls based on IgG subclass profiles.
  • To characterize the temporal dynamics and intrathecal synthesis of HSV-specific IgG subclasses in HSVE patients.

Main Methods:

Related Experiment Videos

  • Analysis of serum and CSF samples from patients with diagnosed HSVE, non-HSVE encephalitis, and healthy controls.
  • Detection of IgG subclasses (IgG1-4) specific to HSV, CMV, and VZV using serological assays.
  • Assessment of intrathecal antibody synthesis and temporal patterns of IgG subclass responses.

    • Main Results:

    • HSV-specific antibodies, particularly IgG1, IgG3, and IgG4, were detected in HSVE patients.
    • HSV IgG3 was often absent early in the disease but appeared later, differentiating it from VZV responses.
    • Intrathecal synthesis of minor HSV IgG subclasses (IgG3, IgG4) was observed earlier than total HSV IgG synthesis.

    Conclusions:

    • HSV IgG subclass analysis in CSF can serve as a valuable marker for diagnosing HSVE.
    • The distinct IgG subclass patterns, especially the presence and timing of IgG3 and IgG4, aid in differentiating HSVE from other neurological conditions.
    • Early detection of intrathecal synthesis of specific HSV IgG subclasses may improve diagnostic accuracy in HSVE.