[Prostate sarcoma: A retrospective analysis of 26 cases]

Area of Science:

• Urologic Oncology
• Surgical Pathology
• Medical Oncology

Background:

• Prostate sarcoma is an exceptionally rare and aggressive malignancy.
• Limited clinical data exists regarding its diagnosis, treatment, and prognostic factors.
• Understanding the characteristics of prostate sarcoma is essential for improving patient management.

Purpose of the Study:

• To review the clinical experience with prostate sarcoma diagnosis and treatment.
• To analyze the clinical and prognostic features of this rare cancer.
• To evaluate treatment outcomes and identify potential strategies for improved prognosis.

Main Methods:

• Retrospective analysis of 26 prostate sarcoma cases treated between June 1998 and March 2018.
• Patient data included age, prostate-specific antigen (PSA) levels, and diagnostic methods (prostatic biopsy, transurethral resection of the prostate - TURP).
• Pathological examination confirmed sarcoma subtypes, and patient follow-up data was collected.

Main Results:

• Common subtypes included leiomyosarcoma (11 cases), rhabdomyosarcoma (6 cases), and spindle cell sarcoma (4 cases).
• Of 24 patients followed, 21 died within 12 months and 3 within 13-18 months post-diagnosis.
• All deaths were attributed to extensive metastases, highlighting the aggressive nature of the disease.

Conclusions:

• Prostate sarcoma is a rare, highly aggressive malignancy with a dismal prognosis.
• Surgery is currently the primary treatment modality.
• A multidisciplinary approach to diagnosis and treatment may offer a better prognosis for patients with prostate sarcoma.