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Updated: Dec 25, 2025

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[Neurophysiological mechanisms of ejaculation].

Qi-Jie Zhang1, Jia-Dong Xia1, Ning-Hong Song1

  • 1Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China .

Zhonghua Nan Ke Xue = National Journal of Andrology
|March 27, 2020
PubMed
Summary
This summary is machine-generated.

Male sexual behavior involves complex regulation of ejaculation by spinal and supraspinal centers. This review explores the neural circuits and neurotransmitters involved in ejaculation control and reward.

Keywords:
neurophysiologyneurotransmittertreatmentejaculation

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Area of Science:

  • Neuroscience
  • Reproductive Biology
  • Behavioral Science

Background:

  • Male sexual behavior culminates in ejaculation, a process regulated by neural generators.
  • The spinal ejaculation generator integrates sensory input, while supraspinal areas modulate timing and context.
  • Ascending signals reach brain regions like the thalamus, hypothalamus, limbic system, and cortex, interacting with olfactory information.

Purpose of the Study:

  • To review the neural circuits controlling ejaculation.
  • To elucidate the roles of neurotransmitters in ejaculation.
  • To provide theoretical insights for treating ejaculation-related disorders.

Main Methods:

  • Literature review of studies on ejaculation control.
  • Analysis of neural pathways involved in ejaculation.
  • Discussion of neurotransmitter functions in sexual behavior.

Main Results:

  • Ejaculation involves a complex interplay between spinal and supraspinal control centers.
  • The medial preoptic nucleus and brainstem are crucial for ejaculation release and reward.
  • Neurotransmitters significantly influence ejaculation processes.

Conclusions:

  • Understanding ejaculation circuits and neurotransmitters is key to comprehending male sexual function.
  • This knowledge can inform the diagnosis and treatment of ejaculation dysfunction.
  • Further research is needed to fully elucidate facilitatory and inhibitory mechanisms.