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Genomic Alteration in Metastatic Breast Cancer and Its Treatment

Allen Li1, Stephen M Schleicher2, Fabrice Andre3

  • 1Department of Hematology Oncology, Oregon Health & Science University, Knight Cancer Institute, Portland, OR.

American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting
|March 28, 2020
PubMed

Insights

Metastatic breast cancer (mBC) treatments are improving, but resistance necessitates new strategies. Understanding genomic alterations like PIK3CA and BRCA1/2 mutations is key to developing targeted therapies for better patient outcomes.

Area of Science:

  • Oncology
  • Genomics
  • Precision Medicine

Background:

  • Metastatic breast cancer (mBC) accounts for most breast cancer fatalities.
  • While novel therapies improve outcomes, resistance remains a significant challenge, highlighting the need for new treatment approaches.
  • Genomic alterations in mBC present emerging therapeutic targets.

Purpose of the Study:

  • To review the role of genomic alterations in mBC.
  • To discuss technologies for mutation detection and interpretation.
  • To emphasize the clinical impact of understanding these alterations for precision medicine in breast oncology.

Main Methods:

  • Review of recent investigations into mBC genomic alterations.
  • Analysis of FDA-approved targeted therapies for PIK3CA and BRCA1/2 mutations.
  • Discussion of mutation detection and interpretation technologies.

Main Results:

  • Targeted therapies against PIK3CA and germline BRCA1/2 mutations are FDA-approved for mBC.
  • These targeted therapies demonstrate clinical benefit for patients with specific mBC genomic alterations.
  • Genomic alterations offer promising targets for novel therapeutic strategies.

Conclusions:

  • Familiarity with mBC genomic alterations is crucial for clinicians.
  • Understanding mutation detection, interpretation, and clinical impact supports precision medicine.
  • Targeted therapies based on genomic profiling are advancing mBC treatment.

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