Related Experiment Video
Updated: Dec 25, 2025
09:37
An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
3.9K
Bioinformatical study on the proteomics and evolution of SARS-CoV
Shuqun Liu1, Tao Guo1, Xinglai Ji1
1Institute of Bioinformatics, Department of Biological Sciences and Biotechnology, Tsinghua University, 100084 Beijing, China.
Chinese Science Bulletin = Kexue Tongbao
|March 28, 2020
Summary
Severe acute respiratory syndrome (SARS) is caused by a novel coronavirus (SARS-CoV). This study analyzes SARS-CoV proteins, revealing its unique classification and phylogenetic relationship to other coronaviruses, aiding vaccine development.
Area of Science:
- Virology
- Proteomics
- Bioinformatics
Background:
- A novel coronavirus, SARS-CoV, identified as the cause of SARS.
- Understanding SARS-CoV protein functions and evolutionary relationships is crucial.
Purpose of the Study:
- To analyze the physiochemical properties and functions of SARS-CoV proteins.
- To determine the classification and phylogenetic relationship of SARS-CoV with other coronaviruses.
Main Methods:
- Calculation of physiochemical properties (molecular weight, isoelectric point, extinction coefficient) for SARS-CoV proteins.
- Prediction of transmembrane segments and subcellular localization (SubLocation).
- Homology sequence alignment and phylogenetic analysis against other coronaviruses.
Main Results:
- SARS-CoV is a novel coronavirus, distinct from previously known groups.
- SARS-CoV shows closer evolutionary relationships to Bovine coronavirus (Bo-CoV) and Murine hepatitis virus (MHV).
Conclusions:
- The study provides a comprehensive analysis of SARS-CoV proteins.
- Findings aid experimental proteomics and the development of SARS-CoV antiviral vaccines.
Related Concept Videos
01:33Proteomics
9.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
9.2K
02:54Evolutionary Relationships through Genome Comparisons
6.8K
Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
6.8K
02:50Conjugated Proteins
26.0K
Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
26.0K
01:05Single Nucleotide Polymorphisms-SNPs
17.7K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.7K
02:02Genomics
39.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
39.5K
02:05Gene Evolution - Fast or Slow?
7.9K
The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...
In contrast, regions which code...
7.9K