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Related Experiment Video

Updated: Dec 25, 2025

Live Imaging and Quantification of Viral Infection in K18 hACE2 Transgenic Mice Using Reporter-Expressing Recombinant SARS-CoV-2
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Reovirus, isolated from SARS patients.

Qing Duan1, Hong Zhu1, Yi Yang2

  • 11Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, 100071 Beijing, China.

Chinese Science Bulletin = Kexue Tongbao
|March 28, 2020
PubMed
Summary

Reovirus was isolated from patients with Severe Acute Respiratory Syndrome (SARS) in Beijing, suggesting a potential co-infection. Further investigation is needed to confirm the role of this unique reovirus in the SARS outbreak.

Keywords:
SARScoronaviruselectron microscopyreovirus

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Area of Science:

  • Virology
  • Infectious Diseases
  • Respiratory Illnesses

Background:

  • Severe Acute Respiratory Syndrome (SARS) significantly impacted Beijing.
  • The SARS-associated coronavirus was identified as the primary cause.
  • Potential for co-infections in SARS cases was considered.

Purpose of the Study:

  • To investigate the potential co-infection in SARS patients.
  • To identify and characterize any co-infecting agents.
  • To explore the association between reovirus and the SARS outbreak.

Main Methods:

  • Isolation of viruses from throat swabs of SARS patients.
  • Electron microscopy for viral identification.
  • Serological testing for reovirus antibodies.
  • DNA sequencing of viral gene fragments (S2 gene).
  • Preliminary animal experiments (mice inoculation).

Main Results:

  • Reovirus was isolated from SARS patients, including the index case.
  • Electron microscopy confirmed characteristic reovirus morphology.
  • Serological evidence of reovirus response in 24 out of 38 SARS cases.
  • Sequencing identified a unique reovirus (orthoreovirus).
  • Mouse inoculation with reovirus led to atypical pneumonia and death.

Conclusions:

  • Reovirus was detected in SARS patients, suggesting a possible co-infection.
  • A unique strain of orthoreovirus was identified.
  • Reovirus may play a role in atypical pneumonia observed in some SARS cases.
  • Further research is required to establish a definitive link between reovirus and the SARS outbreak.