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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
Published on: May 10, 2024
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Eosinophilic pancreatitis: a rare or unexplored disease entity?
Murli Manohar1,2, Alok K Verma1, Gulshan Singh3
1Department of Medicine, Section of Pulmonary Diseases, Tulane Eosinophilic Disorders Centre, Tulane University School of Medicine, New Orleans, LA, USA.
Przeglad Gastroenterologiczny
|March 28, 2020
Summary
Eosinophilic pancreatitis (EP) involves eosinophil buildup in the pancreas, often mimicking tumors. This review explores EP
Area of Science:
- Gastroenterology
- Pathology
- Oncology
Background:
- Eosinophilic pancreatitis (EP) is characterized by eosinophil accumulation in pancreatic tissue.
- EP often presents as a pancreatic tumor with obstructive jaundice, frequently diagnosed post-resection.
- Histological findings include various inflammatory patterns with eosinophils, eosinophilic phlebitis, and pseudocyst formation.
Purpose of the Study:
- To review current understanding of eosinophilic pancreatitis.
- To assess the role of eosinophils in pancreatic fibrosis and malignancy.
Main Methods:
- Literature review of case reports and existing studies on eosinophilic pancreatitis.
- Analysis of histological patterns and clinical presentations associated with EP.
- Examination of serum IgE levels and eosinophil counts in EP patients.
Main Results:
- EP is rare, with limited case reports available.
- Distinct histological patterns of eosinophilic infiltration are observed in EP.
- Elevated serum IgE and systemic eosinophilia are associated with EP.
Conclusions:
- The significance of eosinophils in pancreatitis remains under-established due to limited data.
- Eosinophils may play a role in promoting pancreatic fibrosis and malignancy.
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