[Primary testicular diffuse large B-cell lymphoma: A clinicopathological analysis].

Area of Science:

• Oncology
• Hematology
• Pathology

Background:

• Primary testicular diffuse large B-cell lymphoma (DLBCL) is a rare extranodal non-Hodgkin lymphoma.
• It predominantly affects elderly males and can present with unilateral testicular enlargement.

Purpose of the Study:

• To investigate the clinicopathological features of primary testicular DLBCL.
• To determine the immunophenotype and treatment outcomes.
• To review relevant literature for a comprehensive understanding.

Main Methods:

• Retrospective analysis of 23 primary testicular DLBCL cases.
• Evaluation of pathomorphological characteristics and immunohistochemical markers.
• Review of existing literature on testicular lymphoma.

Main Results:

• The study included 23 patients aged 48-76 years, with painless unilateral testicular swelling as the primary symptom.
• Histologically, diffuse infiltration by large atypical B-cells was observed.
• Immunohistochemistry confirmed B-cell markers; follow-up showed a 4/5 survival rate.

Conclusions:

• Primary testicular DLBCL is a rare entity with aggressive behavior, often diagnosed late in elderly males.
• Histopathology and immunohistochemistry are vital for accurate diagnosis and differential diagnosis.
• Early and accurate diagnosis is critical for effective management.