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Eosinophilic peritonitis induced by sucroferric oxyhydroxide.
Saori Minato1, Haruhisa Miyazawa1, Taisuke Kitano1
1Division of Nephrology, First Department of Integrated Medicine, Saitama Medical Center, Jichi Medical University, Japan.
Summary
Sucroferric oxyhydroxide, an iron-based phosphate binder, can cause eosinophilic peritonitis in patients undergoing peritoneal dialysis. Discontinuation of the drug led to symptom improvement, highlighting its role in this rare complication.
Area of Science:
- Nephrology
- Gastroenterology
- Clinical Pharmacology
Background:
- Continuous ambulatory peritoneal dialysis (CAPD) is a treatment for end-stage renal disease.
- Phosphate binders are commonly prescribed to manage hyperphosphatemia in dialysis patients.
- Sucroferric oxyhydroxide is an iron-based phosphate binder used to control serum phosphate levels.
Observation:
- A 49-year-old woman on CAPD developed eosinophilic peritonitis.
- The condition arose two months after initiating sucroferric oxyhydroxide.
- The patient had underlying congenital right kidney hypoplasia and chronic glomerulonephritis.
Findings:
- A drug-induced lymphocyte stimulation test confirmed sucroferric oxyhydroxide as the causative agent.
- Eosinophilic peritonitis resolved after discontinuing sucroferric oxyhydroxide.
- No immunosuppressive therapy was required for the resolution of peritonitis.
Implications:
- This case highlights a rare adverse effect of sucroferric oxyhydroxide.
- Physicians should consider sucroferric oxyhydroxide-induced eosinophilic peritonitis in dialysis patients with compatible symptoms.
- Prompt drug withdrawal can effectively manage this complication without immunosuppression.
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