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Related Experiment Video

Updated: Dec 25, 2025

Humanized Mediator Release Assay as a Read-Out for Allergen Potency
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Tripterine: A Potential Anti-Allergic Compound.

Bao-Jun Zhu1, Ze-Quan Qian1, Hui-Run Yang1

  • 1Department of Pediatrics, Putuo Hospital of Traditional Chinese Medicine, East of Second Floor Ward, 19 Wenkang Street, Putuo District, Zhoushan, Zhejiang 316100, China.

Current Pharmaceutical Biotechnology
|March 29, 2020
PubMed
Summary

Tripterine (TRI) effectively combats allergic reactions by inhibiting histamine release from mast cells. This compound shows significant potential for treating mast cell-mediated allergic diseases.

Keywords:
Allergic Rhinitis (AR)Human Mast Cells (HMC-1)Seasonal Allergic Rhinitis (SAR)Systemic anaphylactic shockTripterine (TRI)skin allergies

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Area of Science:

  • Pharmacology
  • Immunology
  • Allergy Research

Background:

  • Tripterine (TRI), derived from Tripterygium wilfordii, exhibits anti-inflammatory, immunosuppressive, and anti-tumor properties.
  • Its immunosuppressive characteristics suggest potential therapeutic applications for allergic diseases.

Purpose of the Study:

  • To investigate the anti-allergic effects of Tripterine (TRI).

Main Methods:

  • In vivo and in vitro experiments were conducted.
  • Histamine release from rat peritoneal mast cells was measured.
  • Systemic anaphylactic shock and skin allergy models were utilized.
  • Inflammatory factor expression in Human Mast Cells (HMC-1) was assessed.
  • An animal model of allergic rhinitis was employed.

Main Results:

  • TRI significantly inhibited histamine release from mast cells, outperforming disodium cromoglyceride.
  • TRI suppressed systemic anaphylactic shock and IgE-induced skin allergies.
  • TRI reduced inflammatory factor secretion in HMC-1 cells.
  • Oral or nasal administration of TRI decreased allergy symptoms, histamine, IgE, inflammatory factors, and cells in an allergic rhinitis model.

Conclusions:

  • Tripterine (TRI) demonstrates significant potential as an active immunoregulatory factor for treating mast cell-mediated allergic diseases.