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Establishing a normative database for quantitative pupillometry in the pediatric population
Sanket S Shah1, Hantamalala Ralay Ranaivo2, Rebecca B Mets-Halgrimson1,2
1Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
BMC Ophthalmology
|March 29, 2020
Summary
This study establishes normative pupillary size and function data for children using quantitative pupillometry. Findings reveal correlations between age and pupil metrics, providing valuable clinical screening tools for pediatric eye assessments.
Area of Science:
- Ophthalmology
- Pediatric Medicine
- Neuroscience
Background:
- Pupillary evaluation is essential for physical exams, aiding in optic nerve dysfunction assessment.
- Standardized normative data for scotopic pupillary size and function in pediatric populations are lacking.
- Establishing these norms is critical for accurate clinical interpretation.
Purpose of the Study:
- To establish normative data for scotopic pupillary size and function in a pediatric clinical setting.
- To provide a baseline for assessing optic nerve health in children.
- To evaluate the utility of quantitative pupillometry in pediatric eye exams.
Main Methods:
- Prospective pupillometry measurements were performed on pediatric patients (<18 years) with normal eye evaluations.
- Quantitative data collected included maximum (MAX) and minimum (MIN) diameters, constriction percentage (CON), latency (LAT), constriction velocities (ACV, MCV), average dilation velocity (ADV), and recovery time (T75).
- Iris color was categorized as light, intermediate, or dark.
Main Results:
- 196 eyes from 101 participants (ages 1-17) were analyzed, with mean MAX 6.6 mm and MIN 4.7 mm.
- Significant positive correlations were observed between age and MAX, MIN, and CON.
- Males exhibited significantly greater maximum constriction velocity (MCV) and constriction percentage (CON) than females (p < 0.05).
Conclusions:
- Quantitative pupillometry serves as a valuable screening tool for pediatric patients.
- Normative data were successfully established for scotopic pupillary size and function in this cohort.
- Age and sex are significant factors influencing pupillary responses in children.
