Related Experiment Video
Updated: Dec 25, 2025

Automated Robotic Liquid Handling Assembly of Modular DNA Devices
Published on: December 1, 2017
Protein assembly systems in natural and synthetic biology
Giulio Chiesa1,2, Szilvia Kiriakov1,2, Ahmad S Khalil3,4,5
1Biological Design Center, Boston University, Boston, MA, 02215, USA.
Abstract:
The traditional view of protein aggregation as being strictly disease-related has been challenged by many examples of cellular aggregates that regulate beneficial biological functions. When coupled with the emerging view that many regulatory proteins undergo phase separation to form dynamic cellular compartments, it has become clear that supramolecular assembly plays wide-ranging and critical roles in cellular regulation. This presents opportunities to develop new tools to probe and illuminate this biology, and to harness the unique properties of these self-assembling systems for synthetic biology for the purposeful manipulation of biological function.
Related Concept Videos
Protein Complex Assembly
Many viruses self-assemble into a fully functional unit using the infected host cell to...
Protein Complex Assembly
Assembly of Cytoskeletal Filaments
Synthetic Biology
Golden rice
Golden rice is a genetically modified...
Assembly of Signaling Complexes
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
Genome Annotation and Assembly

