Paired CT Measures of Emphysema and Small Airways Disease and Lung Function and Exercise Capacity in Smokers with...

Bronchiectasis (BE) is associated with chronic obstructive pulmonary disease (COPD), but emphysema and small airways disease, main pathologic features of COPD, have been sparsely studied in BE. We aimed to objectively assess those features in smokers with and without radiographic BE and examine its relationships to airflow obstruction and exercise capacity.

We measured emphysema and small airways disease on paired inspiratory-expiratory computed tomography (CT) scans with the parametric response map (PRM^EMPH and PRM^SAD) method in 1184 smokers with and without radiographic BE. PRM^SAD and PRM^EMPH are expressed as the percentage of lung area. Clinical, spirometry, and exercise capacity data were measured with standardized methods. The differences in PRM^SAD and PRM^EMPH between subjects with and without radiographic BE were assessed using multivariable linear regression analysis, and their associations with FEV₁ and six-minute walk test (6MWT) were assessed with generalized linear models.

Out of 1184 subjects, 383 (32%) had radiographic BE. PRM^EMPH but not PRM^SAD was higher in subjects with radiographic BE than those without radiographic BE in adjusted models. Subjects with radiographic BE and PRM^EMPH (defined as ≥5% on paired CTs) had lower FEV₁ (least square mean, 1479 mL vs. 2350 mL p < 0.0001) and 6MWT (372 m vs. 426 m p = 0.0007) than those with radiographic BE alone in adjusted models.

Smokers with radiographic BE have an increased burden of emphysema on paired CTs, and those with radiographic BE and emphysema have lower airflow and exercise capacity.