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Small Fiber Polyneuropathy in Hunner Lesion and Non-Hunner Lesion Interstitial Cystitis/Bladder Pain Syndrome
Esther Han1, Kim A Killinger, Katherine M Turner1
1From the Beaumont Health.
Female Pelvic Medicine & Reconstructive Surgery
|March 29, 2020
Summary
Small fiber polyneuropathy (SFPN) was diagnosed in 60% of non-Hunner lesion interstitial cystitis/bladder pain syndrome (IC/BPS) patients versus 40% of Hunner lesion IC/BPS patients. Further research is needed to understand SFPN
Area of Science:
- Urology
- Neurology
- Pathology
Background:
- Interstitial cystitis/bladder pain syndrome (IC/BPS) is a chronic condition.
- Small fiber polyneuropathy (SFPN) is increasingly recognized as a potential contributor to IC/BPS.
- Distinguishing between Hunner lesion (HL) and non-Hunner lesion (NHL) IC/BPS is clinically relevant.
Purpose of the Study:
- To investigate differences in SFPN diagnosis between HL IC/BPS and NHL IC/BPS.
- To compare the prevalence of SFPN in these two IC/BPS subtypes.
Main Methods:
- A pilot study included 20 women diagnosed with IC/BPS.
- Two punch biopsies (distal leg and thigh) were obtained for intraepidermal nerve fiber density assessment.
- SFPN diagnosis was confirmed by intraepidermal nerve fiber density below the fifth percentile.
Main Results:
- The study included 10 HL IC/BPS and 10 NHL IC/BPS patients.
- SFPN was diagnosed in 60% of NHL IC/BPS patients compared to 40% of HL IC/BPS patients.
- No significant differences were observed in SFPN positivity or symptom scores between the groups.
Conclusions:
- NHL IC/BPS patients showed a higher prevalence of SFPN (60%) than HL IC/BPS patients (40%).
- These findings align with previous research suggesting a link between SFPN and IC/BPS.
- Larger studies are warranted to fully elucidate the role of SFPN in IC/BPS.
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