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Loricrin: Past, Present, and Future.

Yosuke Ishitsuka1, Dennis R Roop2

  • 1Department of Dermatology, Faculty of Medicine, University of Tsukuba 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan.

International Journal of Molecular Sciences
|March 29, 2020
PubMed
Summary
This summary is machine-generated.

Loricrin, a key protein in skin barrier formation, is dispensable for permeability but crucial for skin homeostasis. Its absence impacts skin health more than previously understood, affecting multiple physiological aspects.

Keywords:
Langerhans cellatopycornified cell envelopesdisulfide cross-linkageloricrinstratum corneumthiolε-(γ-glutamyl) lysine cross-linkage

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Area of Science:

  • Dermatology and Genetics
  • Biochemistry and Biophysics

Background:

  • Epidermal terminal differentiation forms the skin's protective barrier.
  • Genetic defects in the stratum corneum (SC) cause skin diseases like ichthyoses.
  • Amniotes evolved cornification for mechanical resilience and desiccation tolerance via cornified cell envelopes (CE).

Purpose of the Study:

  • To review the functional significance of loricrin, a major CE component.
  • To explore loricrin's role beyond the SC permeability barrier.
  • To discuss loricrin's impact from biochemical, genetic, pathological, metabolic, and immunological perspectives.

Main Methods:

  • Literature review of aggregate evidence on loricrin function.
  • Analysis of loricrin knockout (LKO) mouse models.
  • Examination of biochemical, genetic, and pathological data related to loricrin.

Main Results:

  • Loricrin is dispensable for the SC permeability barrier function.
  • Loricrin knockout mice exhibit broader impacts on skin homeostasis than anticipated.
  • Loricrin's thiol-rich properties are significant for skin physiology.

Conclusions:

  • Loricrin plays a multifaceted role in skin homeostasis beyond barrier permeability.
  • Further research into loricrin's functions is warranted from various scientific angles.
  • Understanding loricrin is key to addressing diverse skin pathologies.