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Functionalized, Vertically Super-Aligned Multiwalled Carbon Nanotubes for Potential Biomedical Applications.

Patrick P Komane1,2, Pradeep Kumar1, Yahya E Choonara1

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|March 29, 2020
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Summary

This study developed functionalized carbon nanotubes for early detection and treatment of neurological diseases like ischemic stroke. These non-toxic nanotubes show promise for advanced theranostic biomedical applications.

Keywords:
PEGylationchemical vapor depositioncontact anglemultiwalled carbon nanotubesnanoelectrodesilicon wafer

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • Ultrasensitive diagnostic tools are lacking for early detection of neurological diseases, including ischemic stroke.
  • Effective intervention is hindered by challenges in diagnosing and treating these conditions.
  • Carbon nanotubes offer potential solutions for the theranostic challenges in neurological disorders.

Purpose of the Study:

  • To synthesize and functionalize carbon nanotubes for potential applications in diagnosing and treating neurological diseases.
  • To explore the use of vertically aligned multiwalled carbon nanotubes (VA-MWCNTs) for ischemic stroke detection and therapy.
  • To develop a carbon-based electrode for neurological disease diagnostics.

Main Methods:

  • Vertically aligned multiwalled carbon nanotubes (VA-MWCNTs) were purified, carboxylated, acylated, and PEGylated.
  • Carbon nanotubes (CNTs) were characterized using SEM, TEM, OCA, DLS, CV, and EIS.
  • VA-MWCNTs were incorporated into epoxy resin to design a carbon-based electrode for diagnostic applications.
  • The non-toxicity of functionalized MWCNTs was assessed using PC-12 neuronal cells.

Main Results:

  • Purified and functionalized VA-MWCNTs were successfully synthesized.
  • Characterization confirmed specific structural and surface properties after treatment and PEGylation.
  • The developed carbon-based electrode showed potential for diagnostic applications.
  • Functionalized MWCNTs exhibited no toxicity to PC-12 neuronal cells.

Conclusions:

  • Vertically super-aligned MWCNTs were successfully synthesized and functionalized.
  • These functionalized MWCNTs hold potential for theranostic biomedical applications in neurological disorders.
  • The study paves the way for improved diagnostics and therapeutics for conditions like ischemic stroke.