Related Experiment Video

Updated: Dec 25, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
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In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

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Circad: a comprehensive manually curated resource of circular RNA associated with diseases

Mercy Rophina1, Disha Sharma1,2, Mukta Poojary1,2

  • 1Genome Informatics Department, CSIR-Institute of Genomics and Integrative Biology, Mathura Road, District-South Delhi, New Delhi-110025, India.

Database : the Journal of Biological Databases and Curation
|March 29, 2020
PubMed

Insights

Circular RNAs (circRNAs) are key disease biomarkers. A new database, CircAD, offers over 1300 circRNAs linked to 150 diseases, aiding biomarker research and functional studies.

Area of Science:

  • Molecular Biology
  • Genomics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are novel RNA isoforms formed by back-splicing.
  • circRNAs are expressed across species and play roles in various diseases.
  • Emerging evidence highlights circRNAs as potential disease biomarkers.

Purpose of the Study:

  • To create a comprehensive, manually curated database of disease-associated circRNAs.
  • To provide researchers with a valuable resource for studying circRNAs in disease.
  • To facilitate the use of circRNAs as biomarkers and for functional investigations.

Main Methods:

  • Manual curation of scientific literature for disease-associated circRNAs.
  • Database development integrating circRNA information with disease classifications (ICD codes).
  • Inclusion of primer details, assay information, and statistical data for selected circRNAs.

Main Results:

  • The CircAD database contains over 1300 circRNAs linked to 150 diseases.
  • circRNAs are mapped to 113 International Statistical Classification of Diseases (ICD) codes.
  • The database provides primer sequences, assay details, fold changes, and statistical significance.

Conclusions:

  • CircAD is a unique and comprehensive resource for disease-associated circRNAs.
  • The database supports research into circRNAs as biomarkers and for functional studies.
  • CircAD offers ready-to-use primer information for experimental applications.

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