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Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment
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Antibiotics promote abdominal fat accumulation in broilers.

Dongfeng Li1, Kun Zhang1, Zaixu Pan1

  • 1College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, China.

Animal Science Journal = Nihon Chikusan Gakkaiho
|March 29, 2020
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Summary
This summary is machine-generated.

Antibiotics like chlortetracycline and tylosin increase abdominal fat in broilers by enhancing fat absorption and synthesis. This occurs without directly affecting fat cells, indicating an indirect regulatory mechanism.

Keywords:
abdominal fat depositionantibioticbroilergene expressionregulatory mechanism

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Area of Science:

  • Animal Science
  • Biochemistry
  • Molecular Biology

Background:

  • Antibiotics are used to promote animal growth, but raise concerns about residues and resistance.
  • The impact of antibiotic use on animal metabolism, specifically fat deposition, requires further investigation.

Purpose of the Study:

  • To evaluate the effects of chlortetracycline and tylosin on abdominal fat deposition in broilers.
  • To investigate the molecular mechanisms underlying antibiotic-induced fat accumulation.

Main Methods:

  • Broilers were fed diets supplemented with chlortetracycline and tylosin.
  • Abdominal fat weight, blood lipid profiles, and gene expression in adipose tissue were analyzed.
  • In vitro studies using preadipocytes were conducted to assess direct effects.

Main Results:

  • Antibiotic supplementation significantly increased abdominal fat weight, percentage, and blood triglyceride and cholesterol levels.
  • Gene expression of PPARγ, DGAT2, LPL, and FABP4 in abdominal fat tissue was upregulated.
  • Antibiotics did not directly affect fat content or gene expression in preadipocytes.

Conclusions:

  • Antibiotics induce fat deposition in broilers indirectly by stimulating intestinal fat absorption and liver fat synthesis.
  • The findings highlight a complex regulatory pathway involving specific genes in adipose tissue.