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Time-Resolved Fluorescence Anisotropy from Single Molecules for Characterizing Local Flexibility in Biomolecules

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Fluorodynamers Displaying Tunable Fluorescence on Constitutional Exchanges in Solution and at Solid Film-Solution

Mingran Si¹, Weijia Zhu¹, Yan Zhang¹

¹Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Avenue, Wuxi, 214122, P. R. China.

Chemistry (Weinheim an Der Bergstrasse, Germany)

|March 29, 2020

Summary

This summary is machine-generated.

Dynamic covalent polymers, or dynamers, show tunable fluorescence for studying material re-composition. These adaptive materials respond to chemical conditions at interfaces, with potential in optical and biomedical fields.

Keywords:

dynamic polymers films fluorescence imine interface reactions

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Area of Science:

Materials Science
Polymer Chemistry
Supramolecular Chemistry

Background:

Dynamic covalent polymers (dynamers) are adaptive materials with tunable properties.
Interface chemistry is crucial for material performance and applications.

Purpose of the Study:

To investigate imine exchange reactions and fluorescence transfer at interfaces involving dynameric films.
To utilize tunable fluorescence for studying the re-composition of solid dynameric films.
To explore the responsiveness of dynameric films to external chemical stimuli.

Main Methods:

Utilizing imine exchange reactions in dynamic covalent chemistry.
Employing fluorescence quenching and transfer mechanisms.
Investigating solid film-solution interfaces.
Testing responsiveness to competing amines and acid/base conditions.

Main Results:

Demonstrated successful fluorescence quenching upon imine formation in designed fluorogens.
Showcased tunable fluorescence for analyzing solid film re-composition.
Observed responsiveness of dynameric films to varying chemical environments (amines, pH).

Conclusions:

Interface dynamic chemistry in dynamers can be effectively studied using fluorescence.
Dynameric films exhibit significant responsiveness, enabling dynamic control.
This research offers insights into interface dynamics with potential for optical and biomedical material development.