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Updated: Dec 25, 2025
Assessment of Dependence in Activities of Daily Living Among Older Patients in an Acute Care Unit
Published on: September 30, 2020
Time trends of delirium rates in the intensive care unit
Sikandar H Khan1, Heidi Lindroth1, Kyle Hendrie2
1Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA; IU Center for Aging Research, Regenstrief Institute, Indianapolis, Indiana, USA; Indiana University Center for Health Innovation and Implementation Science, Indianapolis, Indiana, USA.
Background:
Effects of clinical practice changes on ICU delirium are not well understood.
Objectives:
Determine ICU delirium rates over time.
Methods:
Data from a previously described screening cohort of the Pharmacological Management of Delirium trial was analyzed. Richmond Agitation-Sedation Scale (RASS) and Confusion Assessment Method for the ICU (CAM-ICU) were assessed twice daily. We defined: Any delirium (positive CAM-ICU at any time during ICU stay) and ICU-acquired delirium (1st CAM-ICU negative with a subsequent positive CAM-ICU). Mixed-effects logistic regression models were used to test for differences.
Results:
2742 patient admissions were included. Delirium occurred in 16.5%, any delirium decreased [22.7% to 10.2% (p < 0.01)], and ICU-acquired delirium decreased [8.4% to 4.4% (p = 0.01)]. Coma decreased from 24% to 17.4% (p = 0.04). Later ICU years and higher mean RASS scores were associated with lower odds of delirium.
Conclusions:
Delirium rates were not explained by the measured variables and further prospective research is needed.
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