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Brain tumors in infants less than a year of age
M M Ambrosino1, M Hernanz-Schulman, N B Genieser
1Department of Radiology, New York University, Medical Center, New York.
Insights
Brain tumors in infants under one year old are typically located above the tentorium cerebelli, unlike in older children. These infant brain tumors share similarities with adult tumors but present at a larger size.
Area of Science:
- Pediatric neuro-oncology
- Infant brain tumor research
Background:
- Brain tumors are a significant concern in pediatric oncology.
- Understanding age-specific characteristics of brain tumors is crucial for diagnosis and treatment.
Purpose of the Study:
- To retrospectively analyze the characteristics of brain tumors in infants under one year of age.
- To compare the location, histology, and radiological/pathological features of infant brain tumors with those in older children and adults.
Main Methods:
- Retrospective review of medical charts and CT scans.
- Analysis of tumor location (supratentorial vs. infratentorial).
- Histopathological classification of tumor types.
Main Results:
- Most infant brain tumors were located in the supratentorial region.
- Common histological types included astrocytoma, ganglioglioma, and primitive neuroectodermal tumors.
- Tumors presented at a larger size compared to those in older children and showed similarities to adult tumors radiologically and pathologically.
Conclusions:
- Infant brain tumors exhibit distinct topographical distribution compared to older pediatric populations.
- Histological subtypes and general tumor characteristics show parallels with adult brain tumors.
- Further research into age-specific pediatric brain tumor biology is warranted.
Abstract:
A retrospective examination of brain tumors in infants less than a year of age was undertaken by reviewing their charts and CT scans. In contradistinction to brain tumors found in older children, most tumors were supratentorial in location. The most common histologic types included: astrocytoma, ganglioglioma and primative neuroectodermal tumors. Apart from their larger size at the time of presentation, these tumors were radiologically and pathologically similar to analogous tumors found in adults.