A novel CNN based Alzheimer's disease classification using hybrid enhanced ICA segmented gray matter of MRI

Predicting Alzheimer's Disease (AD) from Mild Cognitive Impairment (MCI) and Cognitive Normal (CN) has become wide. Recent advancement in neuroimaging in adoption with machine learning techniques are especially useful for pattern recognition of medical imaging to assist the physician in early diagnosis of AD. It is observed that the early abnormal brain atrophy and healthy brain atrophy are same. In our endeavor, we proposed a model that differentiation MCI and CN more accurately to escalate early diagnosis of AD. In this paper, we applied both binary and multi class classification, 4463 Slide are divided in to two groups one for training and another for testing at subject level, achieves 100 % of accuracy, 100 % of sensitivity and 100 % of Specificity in the case of AD-CN. 96.2 % of accuracy, 93 % Sensitivity and 100 % Specificity in the case of AD-MCI. 98.0 % of accuracy, 96 % of sensitivity, 100 specificity in the case of CN-MCI. 86.7 % accuracy, 89.6 % of sensitivity, 86.61 % of specificity in the case of AD-MCI-CN. The model is further tested using 10 fold cross validation and obtained 98.0 % of accuracy, to differentiate CN and MCI. Our proposed framework generated results are significantly improving prediction of AD from MCI and CN than compare to the previous work flows and used to differentiate the AD at early stage.