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Related Experiment Video

Updated: Dec 25, 2025

Human Subcutaneous Adipose Tissue Sampling Using a Mini-Liposuction Technique
08:59

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Subcutaneous Fat Reduction with Injected Ice Slurry.

Lilit Garibyan1, Sara Moradi Tuchayi1, Emilia Javorsky1

  • 1From the Wellman Center for Photomedicine, Massachusetts General Hospital; and the Department of Dermatology, Harvard-MIT Health Sciences and Technology, and the Department of Pathology, Harvard Medical School; and Brigham and Women's Hospital.

Plastic and Reconstructive Surgery
|March 30, 2020
PubMed
Summary

Injecting a physiological ice slurry directly into fat tissue offers a novel approach to cryolipolysis (fat freezing). This method resulted in significant fat reduction without damaging surrounding tissues, showing promise for non-surgical body contouring.

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Area of Science:

  • Biomedical Engineering
  • Dermatology
  • Plastic Surgery

Background:

  • Cryolipolysis is a noninvasive technique for subcutaneous fat removal and body contouring.
  • Conventional cryolipolysis relies on topical cooling, limiting fat removal efficacy and location.
  • A novel approach involves direct injection of physiological ice slurry into adipose tissue.

Purpose of the Study:

  • To investigate the efficacy and safety of direct cryolipolysis via physiological ice slurry injection.
  • To compare the fat reduction achieved by ice slurry injection versus conventional methods.

Main Methods:

  • Injectable ice slurries (20% and 40% ice content) were prepared using saline and glycerol.
  • Slurries were injected into the subcutaneous fat of swine.
  • Outcomes were assessed using ultrasound, photography, histology, and gross tissue analysis for up to 8 weeks.

Main Results:

  • A significant reduction in adipose tissue thickness (55 ± 6%) was observed post-injection compared to controls.
  • Fat loss correlated with the injected ice volume.
  • No scarring or damage to surrounding tissues was noted.

Conclusions:

  • Physiological ice slurry injection is a safe and effective method for selective, non-surgical fat removal.
  • This technique represents a promising advancement in body contouring procedures.