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Structural and immunological relationship between laminin and the cysteine proteinase inhibitor stefin
V Keil-Dlouha1, M Paulsson, E Joukoff
1Unité de Chimie des Protéines, Institut Pasteur, Paris, France.
Protein Sequences & Data Analysis
|January 1, 1988
Abstract:
A sequence analogy was found between the C-terminal region of the B1 chain of laminin (residues 1538-1639) and cysteine proteinase inhibitors, in particular the stefin group. The sequence analogous with cysteine proteinase inhibitors occurs in fragment E8 obtained by elastase digestion of laminin. Antibodies raised against E 8 reacted with stefin but not with kininogen or cystatin.