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X-ray studies on piroxicam modifications.

G Reck1, G Dietz, G Laban

  • 1Zentralinstitut für Molekularbiologie, Akademie der Wissenschaften der DDR, Berlin.

Die Pharmazie
|July 1, 1988
PubMed
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Piroxicam, an anti-inflammatory drug, exhibits three distinct crystalline forms. This study details the molecular structures and hydrogen bonding of these different piroxicam modifications.

Area of Science:

  • Pharmaceutical Chemistry
  • Solid-State Chemistry
  • Crystallography

Background:

  • Piroxicam is a non-steroidal anti-inflammatory drug (NSAID).
  • It is known to exist in multiple crystalline forms (polymorphs).
  • Previous studies have characterized some of these forms.

Purpose of the Study:

  • To analyze the crystal structure of the third known modification of piroxicam.
  • To independently determine the crystal structure of the piroxicam monohydrate.
  • To compare the molecular structures and hydrogen bonding patterns across all identified piroxicam forms.

Main Methods:

  • X-ray crystallography for crystal structure determination.
  • Analysis of molecular geometry.
  • Investigation of intermolecular interactions, specifically hydrogen bonding.

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Main Results:

  • The crystal structure of a third piroxicam modification (an anhydrate) was determined.
  • An independent crystal structure analysis of the piroxicam monohydrate was performed.
  • Detailed molecular structures and hydrogen bonding networks for all three forms were elucidated and compared.

Conclusions:

  • Piroxicam exhibits polymorphism, with at least three distinct crystalline forms.
  • Understanding these different forms is crucial for drug formulation and stability.
  • The study provides comprehensive structural data on piroxicam polymorphs.