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The CD40-CD40L Dyad as Immunotherapeutic Target in Cardiovascular Disease

Laura A Bosmans1, Lena Bosch2, Pascal J H Kusters1,3

  • 1Department of Medical Biochemistry, Amsterdam Cardiovascular Sciences (ACS), Amsterdam University Medical Centers, University of Amsterdam, Meibergdreef 15, 1105 AZ, Amsterdam, The Netherlands.

Journal of Cardiovascular Translational Research
|March 31, 2020
PubMed

Insights

Chronic inflammation fuels atherosclerosis. Targeting the CD40-CD40L pathway offers a promising therapeutic strategy to address residual inflammatory risk in atherosclerotic cardiovascular disease.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Inflammation Biology

Background:

  • Chronic inflammation is a key driver of atherosclerosis.
  • Residual inflammatory risk persists despite optimal cardiovascular risk factor management.
  • The CD40-CD40L pathway plays a critical role in immune cell interactions during atherosclerosis development.

Purpose of the Study:

  • To review the role of the CD40-CD40L dyad in atherosclerosis.
  • To discuss novel therapeutic strategies targeting CD40-CD40L in cardiovascular medicine.

Main Methods:

  • Literature review of the CD40-CD40L pathway in atherosclerosis.
  • Analysis of recent studies on CD40-CD40L targeting strategies.

Main Results:

  • The CD40-CD40L dyad is central to inflammatory responses in atherosclerosis.
  • Emerging therapeutic strategies focus on modulating this pathway.

Conclusions:

  • Targeting the CD40-CD40L pathway represents a potential strategy to mitigate residual inflammatory risk in atherosclerotic cardiovascular disease.
  • Further research into CD40-CD40L inhibitors is warranted for cardiovascular medicine.

Keywords:
AtherosclerosisCD40CD40LCardiovascular diseaseImmune checkpoint proteinsInflammation

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