[Multi-modality MRI parameters correlate with the expression of the P504s protein in prostate cancer]

To evaluate the expressions of P504s, 34β-E12, and P63 proteins in PCa and the correlation between the parameters of multi-modality MRI and the expression of P504s.

We retrospectively analyzed the multi-modality MRI data on 43 PCa and 64 non-PCa patients. We obtained the signal intensity-time (SI-T) curves, maximum SI (SImax), time to SImax (Tmax), rate of maximum enhancement (Rmax), and automatically generated apparent diffusion coefficient (ADC) values by conventional, diffusion-weighted and dynamic contrast-enhanced MRI, and determined the expressions of P504s, 34β-E12 and P63 in the prostatic tissues of the patients by immunohistochemistry.

Statistically significant differences were observed between the PCa and non-PCa groups in the positive expressions of P504s (83.7% vs 0%, P < 0.05), 34β-E12 (25.6% vs 91.0%, P < 0.05) and P63 (25.6% vs 86.0%, P < 0.05) in the prostatic tissue, the ADC value (［0.83 ± 0.22］ vs ［1.34 ± 0.28］ ×10－3mm2/s, P < 0.05), Tmax (［21.30 ± 10.78］ vs ［50.22 ± 36.31］ s, P < 0.05), SImax (［1.75 ± 0.39］% vs ［1.24 ± 0.41］%, P < 0.05), and Rmax (［20.20 ± 15.50］% vs ［7.98 ± 6.25］%, P < 0.05). The expression of P504s was correlated negatively with the ADC value and Tmax (r = －0.60 and －0.37, P < 0.01) but positively with SImax and Rmax (r = 0.50 and 0.45, P < 0.01).

The parameters of multi-modality MRI are correlated with the expression of P504s in PCa and can be used as imaging biomarkers for predicting the degrees of its malignancy.