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Uric acid and inflammation in kidney disease
Su Woong Jung1, Su-Mi Kim1, Yang Gyun Kim1
1Division of Nephrology, Department of Internal Medicine, Kyung Hee University, College of Medicine, Seoul, Republic of Korea.
American Journal of Physiology. Renal Physiology
|April 1, 2020
Summary
Elevated uric acid levels (hyperuricemia) may contribute to kidney disease development and progression by activating the immune system and promoting inflammation in kidney cells. Further research clarifies uric acid's role beyond gout.
Area of Science:
- Nephrology
- Immunology
- Biochemistry
Background:
- Asymptomatic hyperuricemia is common in kidney disease patients.
- Epidemiologic studies suggest elevated uric acid contributes to kidney disease, but its role is debated.
- Recent research explores uric acid's biological effects beyond gout.
Purpose of the Study:
- To review the effects of uric acid on the immune system.
- To examine uric acid's impact on kidney cells and inflammation.
- To clarify uric acid's role in kidney disease pathogenesis.
Main Methods:
- Review of experimental studies on uric acid's biological effects.
- Analysis of research on uric acid's impact on immune cells.
- Examination of studies detailing uric acid's effects on kidney cells (tubular, endothelial, vascular smooth muscle).
Main Results:
- Uric acid activates the immune system.
- Uric acid promotes a proinflammatory and profibrotic state in kidney cells.
- Evidence suggests uric acid is a potential modifiable risk factor for kidney disease.
Conclusions:
- Uric acid has significant biological effects beyond gout.
- Uric acid influences kidney disease through immune activation and cellular changes.
- Understanding uric acid's role offers potential therapeutic targets for kidney disease.
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