Related Experiment Video
Updated: Dec 25, 2025
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Application of PLGA nano/microparticle delivery systems for immunomodulation and prevention of allotransplant
Sanaz Keshavarz Shahbaz1, Farshad Foroughi2, Ehsan Soltaninezhad3
1Department of Immunology, School of Medicine, Mashhad University of Medical Sciences , Mashhad, Iran.
Introduction:
Allograft transplantation is an effective end-point therapy to replace the function of an impaired organ. The main problem associated with allotransplantation is the induction of immune responses that results in acute and chronic graft rejection. To modulate the response of the immune system, transplant recipients generally take high dose immunosuppressant drugs for life. These drugs are associated with serious side effects such as infection with opportunistic pathogens and the development of neoplasia.
Areas Covered:
We reviewed the obstacles to successful transplantation and PLGA-based strategies to reduce immune-mediated allograft rejection.
Expert Opinion:
Biomaterial-based approaches using micro- and nanoparticles such as poly (lactic-co-glycolic acid) (PLGA) can be used to achieve controlled release of drugs. This approach decreases the required effective dose of drugs and enables local delivery of these agents to specific tissues and cells, whilst decreasing systemic effects.
