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A comparison of two ulcerogenic techniques.

W P Paré1

  • 1Veterans Administration Medical Center, Perry Point, MD 21902.

Physiology & Behavior
|January 1, 1988
PubMed
Summary
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Younger rats and those subjected to water restraint experienced the most significant stress-induced hypothermia. Water restraint also led to more stomach ulcers in older rats compared to supine restraint.

Area of Science:

  • Physiology
  • Animal Models
  • Stress Research

Background:

  • Stress can induce physiological changes, including hypothermia and gastrointestinal issues.
  • Age can influence the physiological response to stress.
  • Restraint methods vary in their capacity to induce stress responses.

Purpose of the Study:

  • To investigate the impact of different restraint methods (supine vs. water) on stress-induced hypothermia and ulcer formation in rats of varying ages.
  • To compare the severity of physiological stress responses between supine and water restraint.
  • To determine the influence of age on stress susceptibility.

Main Methods:

  • Long Evans rats of three age groups (45, 130, 280 days) were used.
  • Animals were subjected to either supine or water restraint for 2 hours, followed by a 2-hour rest period.

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  • Core body temperature was monitored every 30 minutes, and ulcer incidence was assessed post-restraint.

    • Main Results:

    • Water restraint induced greater stress-induced hypothermia than supine restraint.
    • Younger rats exhibited more pronounced hypothermia regardless of restraint type.
    • Water restraint resulted in significantly more gastric ulcers in 130- and 280-day-old rats compared to supine restraint.

    Conclusions:

    • Water restraint is a more potent stressor than supine restraint, leading to increased hypothermia and ulceration.
    • Younger rats are more susceptible to stress-induced hypothermia.
    • Age modulates the gastrointestinal response to restraint stress, with older rats showing increased ulcer formation under water restraint.