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Updated: Dec 25, 2025
Evaluation of Antimicrobial Activities of Nanoparticles and Nanostructured Surfaces In Vitro
Published on: April 21, 2023
Nanoparticles as a Tool for Broadening Antifungal Activities
Daniele Fernanda Renzi1, Laís de Almeida Campos1, Eduardo Hösel Miranda1
1Pharmaceutical Nanotechnology Laboratory, Universidade Estadual do Centro-Oeste, Alameda Élio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava-PR, Brazil.
Abstract:
Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance, new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery. In this sense, the objective of the present study was to evaluate the contributions of newly developed nanoparticles to the treatment of fungal infections. Studies have shown that nanoparticles generally improve the biopharmaceutical and pharmacokinetic characteristics of antifungals, which is reflected in a greater pharmacodynamic potential and lower toxicity, as well as the possibility of prolonged action. It also offers the proposition of new routes of administration. Nanotechnology is known to contribute to a new drug delivery system, not only for the control of infectious diseases but for various other diseases as well. In recent years, several studies have emphasized its application in infectious diseases, presenting better alternatives for the treatment of fungal infections.
Insights
New nanoparticles offer promising solutions for treating fungal infections, which are increasingly common and resistant to existing drugs. This nanotechnology enhances antifungal drug delivery, improving effectiveness and reducing toxicity.
Area of Science:
- Mycology
- Nanotechnology
- Pharmacology
Background:
- Fungal infections are a growing global health concern with limited treatment options.
- Increasing antifungal resistance necessitates novel therapeutic strategies.
- Nanoparticles show potential for improving drug delivery and efficacy.
Purpose of the Study:
- To evaluate the therapeutic contributions of novel nanoparticles in treating fungal infections.
- To explore how nanoparticles can enhance antifungal drug characteristics.
Main Methods:
- Development of new nanoparticles for drug delivery.
- Evaluation of nanoparticle-loaded antifungals in preclinical models (implied).
Main Results:
- Nanoparticles improve the biopharmaceutical and pharmacokinetic properties of antifungals.
- Enhanced pharmacodynamic potential and reduced toxicity observed.
- Potential for prolonged drug action and novel administration routes.
Conclusions:
- Nanoparticles represent a significant advancement in antifungal drug delivery systems.
- This nanotechnology offers a promising alternative for managing challenging fungal infections.
- Further research into nanoparticle applications for infectious diseases is warranted.
