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Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

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[Flecainid intoxication: Evolution, complications and care of].

H Bensussan¹, K Mhamdi²

¹Cardiologie, DES de cardiologie et médecine vasculaire, CHU de Tours, avenue de la République, 37170 Chambray les Tours, France.

Annales De Cardiologie Et D'Angeiologie

|April 1, 2020

Summary

This summary is machine-generated.

A young man with Asperger syndrome experienced ventricular tachycardia after ingesting flecainide. This case highlights the potential for delayed adverse effects from flecainide, even days after ingestion.

Keywords:

Bicarbonates Effet stabilisant de membrane Flecaine Flécainide Intoxication médicamenteuse volontaire Membrane stabilizing effect Sedation Sédation Ventilation Ventricular tachycardia Voluntary medication intoxication tachycardie ventriculaire

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Area of Science:

Pharmacology
Cardiology
Neurology

Background:

Flecainide is an antiarrhythmic medication.
Asperger syndrome is a neurodevelopmental disorder.

Observation:

A 24-year-old male with Asperger syndrome ingested a significant quantity of flecainide.
The patient developed ventricular tachycardia, a serious adverse effect.

Findings:

The ventricular tachycardia was attributed to flecainide's membrane-stabilizing effect.
Prolonged intensive care unit stay was necessitated by the adverse event.
Literature review indicated mid-term leaching of flecainide, suggesting delayed toxicity.

Implications:

This case underscores the importance of considering delayed toxicity from flecainide, particularly in patients with neurodevelopmental disorders.
Awareness of flecainide leaching is crucial for managing overdose cases.
Further research into flecainide pharmacokinetics and toxicity in specific patient populations is warranted.