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Author Spotlight: Discovering New Alkaloids in Plants with Advanced Mass Spectrometry Techniques
Published on: March 8, 2024
Stemtuberolines A-G, new alkaloids from Stemona tuberosa and their anti-TMV activity
Zhan-Xing Hu1, Qiao An1, Hong-Yu Tang2
1State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang 550002, PR China.
Abstract:
Three new tuberostemoamide-type alkaloids, stemtuberolines A-C (1-3), four new stenine-type alkaloids, stemtuberolines D-G (4-7), together with five known Stemona alkaloids (8-12), were isolated from the roots of Stemona tuberosa. Their structures were elucidated on the basis of comprehensive spectroscopic data analysis. Stemtuberoline C (3) exhibited significant anti-TMV activity with an inhibition rate of 60.48% at the concentration of 50 μg/mL, while that of ningnamycin, the positive control, was 52.89%.
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