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Updated: Dec 25, 2025

A Method to Study the C924T Polymorphism of the Thromboxane A2 Receptor Gene
Published on: April 1, 2019
Association between TLR2 Arg677Trp polymorphism and tuberculosis susceptibility: A meta-analysis
Xiaochun Jin1, Shuzhou Yin1, Youtao Zhang2
1Department of Anesthesiology, Suzhou Kowloon Hospital, Shanghai Jiaotong University School of Medcine, Suzhou, 215028, PR China.
Background:
Toll-like receptor 2 (TLR2) is an important member of TLRs, which is significant in the initial of inflammatory response against bacteria. Several studies have been conducted to investigate the TLR2 Arg677Trp polymorphism and Tuberculosis (TB) susceptibility. Unfortunately, the results of previous studies were inconsistent.
Objectives:
The aim of present study was to investigate the relationship between TLR2 Arg677Trp polymorphisms and TB susceptibility.
Methods:
The association between the TLR2 Arg677Trp polymorphism and TB susceptibility was assessed by odds ratios (OR) together with their 95% confidence intervals (95%CI).
Results:
Six case-control studies were enrolled in the meta-analysis. Overall, significant association between TLR2 Arg677Trp polymorphism and TB risk were found neither under allele contrast (C vs. T: OR = 0.59, 95%CI = 0.28-1.23, P = 0.158) nor under recessive genetic model (CC vs. CT/TT: OR = 0.43, 95%CI = 0.12-1.51, P = 0.188).
Conclusion:
We conclude that TLR2 Arg677Trp polymorphism is not associated with TB susceptibility.
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