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Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: A minireview

Subha Mondal1, Nilanjan Adhikari1, Suvankar Banerjee1

  • 1Natural Science Laboratory, Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, P. O. Box 17020, Jadavpur University, Kolkata, 700032, India.

European Journal of Medicinal Chemistry
|April 1, 2020
PubMed

Insights

Matrix metalloproteinases (MMPs), particularly MMP-9, play key roles in diseases. This review focuses on MMP-9 inhibitors as potential anticancer agents, discussing their structure, function, and therapeutic potential.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Matrix metalloproteinases (MMPs) are zinc-dependent proteolytic enzymes.
  • MMP-9, a prominent MMP, degrades extracellular matrix (ECM) and is implicated in various pathophysiological processes.
  • Dysregulation of MMP-9 is linked to numerous diseases, including cancer.

Purpose of the Study:

  • To review the structure, activation, and function of MMP-9.
  • To discuss current inhibitors of MMP-9 and their therapeutic potential, especially as anticancer agents.
  • To highlight the need for selective MMP-9 inhibitors in cancer treatment.

Main Methods:

  • Literature review focusing on MMP-9 structure, function, and inhibitors.
  • Analysis of existing highly active and selective MMP-9 inhibitors.
  • Discussion of the structural significance of MMP-9 inhibitors.

Main Results:

  • MMP-9's role in ECM degradation and disease pathogenesis is significant.
  • Several MMP-9 inhibitors show high activity and selectivity.
  • No selective MMP-9 inhibitors have successfully passed clinical trials to date.

Conclusions:

  • MMP-9 inhibitors represent a promising therapeutic strategy for cancer.
  • Understanding the structural basis of MMP-9 inhibition is crucial for developing new drugs.
  • Further research is needed to design potent and selective MMP-9 inhibitors for clinical application.
Keywords:
CancerHydroxamateMMP-9MMP-9 inhibitorMatrix metalloproteinase

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