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Updated: Dec 25, 2025

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Use of Artificial Intelligence for Medical Literature Search: Randomized Controlled Trial Using the Hackathon Format
Dominik Schoeb1, Rodrigo Suarez-Ibarrola1, Simon Hein1
1Medical Center - Department of Urology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Background:
Mapping out the research landscape around a project is often time consuming and difficult.
Objective:
This study evaluates a commercial artificial intelligence (AI) search engine (IRIS.AI) for its applicability in an automated literature search on a specific medical topic.
Methods:
To evaluate the AI search engine in a standardized manner, the concept of a science hackathon was applied. Three groups of researchers were tasked with performing a literature search on a clearly defined scientific project. All participants had a high level of expertise for this specific field of research. Two groups were given access to the AI search engine IRIS.AI. All groups were given the same amount of time for their search and were instructed to document their results. Search results were summarized and ranked according to a predetermined scoring system.
Results:
The final scoring awarded 49 and 39 points out of 60 to AI groups 1 and 2, respectively, and the control group received 46 points. A total of 20 scientific studies with high relevance were identified, and 5 highly relevant studies ("spot on") were reported by each group.
Conclusions:
AI technology is a promising approach to facilitate literature searches and the management of medical libraries. In this study, however, the application of AI technology lead to a more focused literature search without a significant improvement in the number of results.
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