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Updated: Jul 25, 2026
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High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents (HPHC)
Published on: May 10, 2016
Toxicokinetics in the evaluation of toxicity data
P G Watanabe1, A M Schumann, R H Reitz
1Mammalian and Environmental Toxicology Research Laboratory, Dow Chemical Company, Midland, Michigan 48674.
Regulatory Toxicology and Pharmacology : RTP
|December 1, 1988
Summary
Toxicokinetics, the study of how substances move through the body, can improve animal toxicity testing. Applying toxicokinetic data and models aids in dose selection and interpreting results for human safety.
Area of Science:
- Toxicology
- Pharmacokinetics
- Biomedical Science
Background:
- Toxicokinetics is an underutilized tool in animal toxicity studies.
- Current application of toxicokinetic data in study design and interpretation is insufficient.
- Understanding biological mechanisms is key to advancing toxicokinetic applications.
Purpose of the Study:
- To highlight the importance and potential of toxicokinetics in toxicity testing.
- To advocate for the effective use of toxicokinetic data in selecting doses for toxicity studies.
- To promote the development and application of physiologically based pharmacokinetic models.
Main Methods:
- Review of toxicokinetic principles and their application in toxicity studies.
- Discussion of physiologically based pharmacokinetic (PBPK) models.
- Analysis of extrapolation between species and routes of administration.
Main Results:
- Toxicokinetic data can be effectively used for dose selection in toxicity studies.
- Physiologically based pharmacokinetic models offer a physiological basis for extrapolation.
- Enhanced understanding of mechanisms of action enables more detailed modeling.
Conclusions:
- Toxicokinetics offers powerful, underutilized tools for improving animal toxicity studies.
- Physiologically based pharmacokinetic models are valuable for interpreting animal toxicity data.
- Future use of PBPK models in setting human exposure limits for non-cancer toxicity is recommended.
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