Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Epinephrine in spinal anesthesia].

H Nolte1, A Kraus

  • 1Institut für Anaesthesiologie, Klinikum Minden, Westfalen.

Regional-Anaesthesie
|October 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dissecting heterogeneity in cortical thickness abnormalities in major depressive disorder: a large-scale ENIGMA MDD normative modelling study.

bioRxiv : the preprint server for biology·2025
Same author

Meta-analyses of the efficacy of pharmacotherapies and sublingual allergy immunotherapy tablets for allergic rhinitis in adults and children.

Rhinology·2021
Same author

Parameter estimation for discretely observed linear birth-and-death processes.

Biometrics·2020
Same author

Short-term effects of simulated microgravity on morphology and gene expression in human breast cancer cells.

Physiology international·2020
Same author

Deubiquitinase USP10 regulates Notch signaling in the endothelium.

Science (New York, N.Y.)·2019
Same author

Sugammadex hypersensitivity and underlying mechanisms: a randomised study of healthy non-anaesthetised volunteers.

British journal of anaesthesia·2018
Same journal

[Epidural blockade for analgesia and treatment of acute pancreatitis].

Regional-Anaesthesie·1991
Same journal

[Comments on the paper by R. Schürg et al. Maternal and neonatal plasma concentrations of bupivacaine during peridural anesthesia for cesarean section].

Regional-Anaesthesie·1991
Same journal

[CSE--the combination of spinal and epidural anesthesia].

Regional-Anaesthesie·1991
Same journal

[A simple technique for estimating the level of analgesia in regional anesthesia].

Regional-Anaesthesie·1991
Same journal

[Knotting of a peridural catheter].

Regional-Anaesthesie·1991
Same journal

[An epidural spinal abscess as a lethal complication of peridural anesthesia].

Regional-Anaesthesie·1991
See all related articles

Adding epinephrine to isobaric bupivacaine for spinal anesthesia prolongs analgesia duration. Optimal results are seen with 1:100,000 epinephrine, while higher concentrations may reduce effects.

Area of Science:

  • Anesthesiology
  • Pharmacology

Context:

  • Isobaric bupivacaine is a common choice for spinal anesthesia.
  • Its efficacy is often enhanced by additives.
  • Epinephrine is frequently used to prolong anesthetic effects.

Purpose:

  • To investigate the dose-dependent effects of epinephrine on the duration and characteristics of spinal anesthesia induced by isobaric bupivacaine.
  • To compare findings with previous research on epinephrine's role in spinal anesthesia.

Summary:

  • Bupivacaine 0.5% with epinephrine demonstrated dose-dependent prolongation of analgesia.
  • Optimal analgesia duration was achieved with 1:100,000 epinephrine.
  • Higher epinephrine concentrations (1:50,000) did not further enhance analgesia and could potentially reduce duration, contradicting some prior studies.

Related Experiment Videos

  • Epinephrine also reduced latency and prolonged motor blockade, particularly at higher concentrations.
  • Sensory and motor function recovery times were primarily influenced by the highest epinephrine concentration.

    • Impact:

    • Provides evidence for optimizing epinephrine concentration in spinal bupivacaine anesthesia for extended pain relief.
    • Highlights potential paradoxical effects of high-dose epinephrine, informing clinical practice and future research.
    • Contributes to understanding the pharmacodynamics of epinephrine in spinal anesthesia.