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Related Experiment Videos

Brigitte Autran1,2,3, Béhazine Combadière1,3, Odile Launay3,4,5

  • 1Sorbonne Universités, UPMC Univ Paris 06, INSERM, U1135, Centre, d'Immunologie et des Maladies Infectieuses (CIMI-, Paris, UMRS 1135), Paris, F-75013, France.

Bulletin De L'Academie Nationale De Medecine
|April 1, 2020
PubMed
Summary

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Systems vaccinology analysis of saRNA immunization identifies an acute innate immune signature correlated with adaptive immunity.

Molecular therapy. Advances·2026
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A Response to the Letter to the Editor: "Re: 'Human Immunodeficiency Virus Impairs Immune Responses to Tumor Neoepitopes Without Altering Mutational Profiles in NSCLC'" by Gokhan Koker and Ozcelik.

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Establishing long-lasting vaccine immunity: insights from mRNA and adjuvanted protein platforms.

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A new definition of human health is needed to better implement One Health.

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Proceedings of the 2023 Annual Scientific Meeting of the French Society of Toxicologic Pathology (SFPT) on Preclinical Development and Therapeutic Applications of mRNA-Based Technologies.

Toxicologic pathology·2025

Modern vaccine successes face challenges from public hesitancy and evolving diseases. New research is crucial for improving vaccine efficacy, safety, and developing innovative solutions for global health threats.

Area of Science:

  • Immunology
  • Microbiology
  • Molecular Biology
  • Genetic Engineering
  • Social Sciences

Context:

  • 20th-century vaccines controlled infectious diseases, but current successes are threatened.
  • Societal vaccine hesitancy necessitates understanding vaccine mechanisms and improving acceptance.
  • Aging populations and at-risk groups require enhanced vaccine immunogenicity and effectiveness.

Purpose:

  • To address challenges in vaccine conservation and expansion.
  • To understand vaccine mechanisms and improve tolerance and acceptability.
  • To drive innovation in vaccine development for emerging epidemics and antibiotic resistance.

Summary:

  • Overcoming challenges to vaccine success requires multidisciplinary research.

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  • Developing novel vaccines for malaria, tuberculosis, and AIDS necessitates new approaches.
  • Advances in molecular, cellular, and genetic engineering are key to future vaccine innovation.

    • Impact:

    • Improved vaccine efficacy and safety for diverse populations.
    • Enhanced public trust and acceptance of vaccination programs.
    • Development of next-generation vaccines to combat global infectious disease threats.