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Macrophage-derived SPARC Attenuates M2-mediated Pro-tumour Phenotypes

Jianwen Hu1, Yongchen Ma2, Ju Ma1

  • 1Department of General Surgery, Peking University First Hospital, Beijing, 100034, PR China.

Journal of Cancer
|April 1, 2020
PubMed
Summary

Secreted protein acidic and rich in cysteine (SPARC) from macrophages can suppress gastric cancer progression. SPARC overexpression in M2 macrophages reduces tumor cell proliferation, migration, and resistance to cell death.

Keywords:
SPARCapoptosisgastric cancermigrationproliferationtumour-associated macrophages

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