Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mutagenicity and Carcinogenicity01:25

Mutagenicity and Carcinogenicity

1.8K
Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...
1.8K
Cancer Prevention02:59

Cancer Prevention

7.5K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
7.5K
Spontaneous and Induced Mutations01:30

Spontaneous and Induced Mutations

1.9K
Spontaneous mutations arise infrequently during DNA replication due to errors in the process. A key factor behind these errors is tautomeric shifts in nitrogenous bases, where bases transition from keto to enol forms or amino to imino forms. This shift can alter base-pairing rules, leading to mutations. Additionally, reactive oxygen species (ROS) arising from aerobic metabolism can damage DNA, resulting in depurination (loss of a purine base) or depyrimidination (loss of a pyrimidine base).
1.9K
Types of Toxins01:36

Types of Toxins

3.1K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
3.1K
Teratogenicity01:07

Teratogenicity

3.9K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.9K
Mutations01:35

Mutations

42.5K
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
42.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Critical Perspective on the Role of Thirdhand Smoke in Tumorigenesis: Initiator or Promoter.

Environment & health (Washington, D.C.)·2026
Same author

Identifying predictive hematological biomarkers for radiation exposure by machine learning in mouse models.

Communications medicine·2026
Same author

A quantitative proteomics dataset for assessment and prediction of low dose X-ray radiation exposure in mice.

bioRxiv : the preprint server for biology·2026
Same author

[Expression of Concern] FHOD1 is upregulated in gastric cancer and promotes the proliferation and invasion of gastric cancer cells.

Oncology letters·2026
Same author

Multiple types of exogenous microparticles coexist in the early human decidua and placental villi.

Environment international·2026
Same author

Retraction: GNA14 silencing suppresses the proliferation of endometrial carcinoma cells through inducing apoptosis and G2/M cell cycle arrest.

Bioscience reports·2026

Related Experiment Video

Updated: Dec 25, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
08:39

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

26.2K

Thirdhand smoke: Genotoxicity and carcinogenic potential.

Bo Hang1, Pin Wang2, Yue Zhao3

  • 1Biological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

Chronic Diseases and Translational Medicine
|April 1, 2020
PubMed
Summary

Thirdhand smoke (THS) is a hidden hazard found indoors. Emerging research on THS genotoxicity and carcinogenicity is crucial for understanding cancer risks and informing tobacco control policies.

Keywords:
CarcinogenesisGenotoxicityThirdhand smokeTobaccoTobacco-specific nitrosamines

More Related Videos

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

9.1K
Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
09:33

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

14.2K

Related Experiment Videos

Last Updated: Dec 25, 2025

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
08:39

Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies

Published on: August 25, 2018

26.2K
Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

9.1K
Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
09:33

Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Published on: March 20, 2018

14.2K

Area of Science:

  • Environmental Health
  • Toxicology
  • Cancer Research

Background:

  • Thirdhand smoke (THS) is residual tobacco smoke in indoor environments.
  • Secondhand smoke (SHS) exposure is a known cancer risk, but THS risks are less understood.
  • THS poses a distinct, underestimated public health hazard, particularly for children.

Purpose of the Study:

  • To summarize existing studies on the genotoxicity and carcinogenic potential of THS exposure.
  • To address the knowledge gap regarding THS and chronic disease risks.
  • To inform tobacco control policies and lifestyle changes.

Main Methods:

  • Review and synthesis of published research on THS genotoxicity.
  • Analysis of studies investigating the carcinogenic potential of THS.
  • Identification of research gaps in THS health effects.

Main Results:

  • Limited studies exist, but they begin to fill the knowledge gap on THS cancer risk.
  • Evidence suggests THS exposure has genotoxic and potentially carcinogenic effects.
  • Further research is needed to fully understand THS associations with cancer and chronic diseases.

Conclusions:

  • THS represents a significant, underappreciated public health concern.
  • Understanding THS genotoxicity and carcinogenicity is vital for cancer prevention.
  • Future studies will be critical for developing effective tobacco control strategies.