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Correlations between low thyroid function and incidence of atrial fibrillation in hypertrophic obstructive

Li-Min Liu1, Li-Shui Shen1, Shang-Yu Liu1

  • 1Department of Cardiovascular Medicine, Clinical EP Lab & Arrhythmia Center, Fuwai Hospital, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China.

Chronic Diseases and Translational Medicine
|April 1, 2020
PubMed

Insights

Hypothyroidism, including overt and subclinical forms, is strongly linked to atrial fibrillation (AF) in patients with hypertrophic obstructive cardiomyopathy (HOCM). This finding suggests thyroid status is crucial for assessing AF risk in HOCM.

Area of Science:

  • Cardiology
  • Endocrinology
  • Internal Medicine

Background:

  • Atrial fibrillation (AF) is a common arrhythmia in hypertrophic obstructive cardiomyopathy (HOCM).
  • Limited data exist on the relationship between thyroid dysfunction and AF incidence in HOCM patients.
  • This study investigates the correlation between thyroid status and AF in a large HOCM cohort.

Purpose of the Study:

  • To determine the association between various thyroid function states and the incidence of AF.
  • To analyze thyroid status in relation to AF occurrence within a cohort of HOCM patients.

Main Methods:

  • Recruited 806 HOCM patients with complete thyroid function and cardiac evaluation data.
  • Classified participants into AF (n=159) and non-AF (n=647) groups based on medical history and Holter monitoring.
  • Assessed thyroid status and analyzed the corresponding incidence of AF.

Main Results:

  • Hypothyroidism was the most prevalent thyroid dysfunction in HOCM patients.
  • AF incidence significantly increased with overt and subclinical hypothyroidism (P=0.022, P=0.007).
  • AF patients showed lower FT3, higher FT4, and increased TSH levels compared to non-AF patients (P<0.001).
  • Multivariable analysis identified low FT3, high FT4, and elevated TSH as independent predictors of AF (P<0.05).

Conclusions:

  • A significant association exists between diminished thyroid function and AF in HOCM.
  • Hypothyroidism, both overt and subclinical, is a valuable indicator for assessing AF incidence in HOCM patients.
Abstract

Keywords:
Atrial fibrillationHypertrophic obstructive cardiomyopathyHypothyroidismThyroid hormone

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