Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fabrication and characterization of osteogenic function of progenitor cell-laden gelatin microcarriers.

Journal of biomedical materials research. Part B, Applied biomaterials·2021
See all related articles

Related Experiment Video

Updated: Dec 25, 2025

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model
08:43

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model

Published on: February 7, 2018

7.9K

Modular microcarrier technologies for cell-based bone regeneration.

Chukwuma E Nweke1, Jan P Stegemann1

  • 1Department of Biomedical Engineering, Ann and Robert H. Lurie Biomedical Engineering Building, University of Michigan, 1101 Beal Avenue, Ann Arbor, MI 48109, USA. jpsteg@umich.edu and Macromolecular Science & Engineering Program, North Campus Research Complex, University of Michigan, 2800 Plymouth Road, Ann Arbor, MI 48109, USA.

Journal of Materials Chemistry. B
|April 1, 2020
PubMed
Summary
This summary is machine-generated.

Microcarriers offer promising solutions for bone regeneration by delivering progenitor cells. This review details materials and methods for enhanced orthopaedic repair using these advanced bone fillers.

More Related Videos

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.5K

Related Experiment Videos

Last Updated: Dec 25, 2025

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model
08:43

Recombinant Collagen I Peptide Microcarriers for Cell Expansion and Their Potential Use As Cell Delivery System in a Bioreactor Model

Published on: February 7, 2018

7.9K
Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect
09:35

Distinctive Capillary Action by Micro-channels in Bone-like Templates can Enhance Recruitment of Cells for Restoration of Large Bony Defect

Published on: September 11, 2015

10.0K
Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration
06:05

Author Spotlight: Enhancing Bone Regeneration with Vascularized Artificial Cartilage Integration

Published on: July 14, 2023

1.5K

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Orthopaedic Surgery

Background:

  • Clinical need for effective bone fillers to repair damaged bone.
  • Development of materials-based strategies for accelerated bone regeneration.
  • Emerging role of cell-based therapies in orthopaedic repair.

Purpose of the Study:

  • To comprehensively review microcarrier technologies for progenitor cell delivery in bone regeneration.
  • To analyze materials and fabrication methods for microcarriers in orthopaedic applications.
  • To assess the in vitro and in vivo efficacy of microcarrier-based bone repair strategies.

Main Methods:

  • Systematic review of literature on microcarrier fabrication and characterization.
  • Categorization of microcarriers based on material composition (polysaccharides, proteins, ceramics, synthetic polymers, composites).
  • Evaluation of studies focusing on osteogenic differentiation and bone defect healing.

Main Results:

  • Microcarriers made from diverse materials (polysaccharides, proteins, ceramics, polymers, composites) effectively support progenitor cells.
  • Fabrication and characterization methods are tailored to specific orthopaedic indications.
  • Demonstrated in vitro osteogenic support and in vivo bone healing capabilities of various microcarrier systems.

Conclusions:

  • Microcarrier-based cell delivery is a viable strategy for enhancing bone regeneration.
  • Material selection and fabrication are critical for optimizing microcarrier performance.
  • Future advancements in microcarrier technology hold significant potential for improved cell-based bone therapies.