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Plasma levels of osteopontin from birth to adulthood

Nasenien Nourkami-Tutdibi1, Norbert Graf2, Rita Beier3

  • 1Hospital for General Pediatrics and Neonatology, Saarland University Medical Center, Homburg/Saar, Germany.

Pediatric Blood & Cancer
|April 1, 2020
PubMed

Insights

Osteopontin (OPN) levels are highest in newborns and decline with age throughout childhood. This study establishes the first reference values for OPN in children, crucial for understanding its role in pediatric health.

Area of Science:

  • Biochemistry
  • Pediatrics
  • Biomarker Research

Background:

  • Osteopontin (OPN) is a known biomarker for various diseases.
  • Limited data exists on OPN's role and reference values in pediatric populations.

Purpose of the Study:

  • Establish OPN reference values in children from birth to young adulthood.
  • Investigate age, gender, and weight-specific differences in pediatric OPN levels.

Main Methods:

  • Collected umbilical cord blood and blood plasma from 117 children.
  • Measured OPN levels using ELISA.
  • Performed statistical analysis to identify age-related trends.

Main Results:

  • Highest OPN blood levels were observed in neonates and infants (0-1 year olds).
  • OPN levels showed a significant age-related decline (Spearman r = -0.874, P < 0.001).
  • OPN levels in adolescents approached adult values by age 14.

Conclusions:

  • This is the first prospective study to provide systematic OPN reference values for children across all age groups.
  • Physiological influences on OPN during childhood development are elucidated.
  • The findings highlight a significant age-related decrease in OPN from birth to young adulthood.
Abstract

Keywords:
biomarkerblood plasmacord bloodoncogeneosteopontinpediatric reference values

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