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Functionalized Multiarmed Polycaprolactones as Biocompatible Tissue Adhesives.

Wei Zhang1, Tianjiao Ji1, Sophie Lyon1

  • 1Laboratory for Biomaterials and Drug Delivery, The Department of Anesthesiology, Critical Care, and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, United States.

ACS Applied Materials & Interfaces
|April 2, 2020
PubMed
Summary
This summary is machine-generated.

New biocompatible polycaprolactone (PCL) tissue adhesives offer strong adhesion without compromising safety. These multiarmed polymers, functionalized with NHS, CHO, or NCO, show promise as advanced surgical glue alternatives.

Keywords:
multiarmedpolycaprolactonestissue adhesive

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Surgical Innovation

Background:

  • Current tissue adhesives face challenges balancing adhesive strength with biocompatibility.
  • Developing novel materials for surgical repair is crucial for improved patient outcomes.

Purpose of the Study:

  • To synthesize and characterize multiarmed polycaprolactones (PCL) as biocompatible tissue adhesives.
  • To investigate the relationship between polymer architecture (number of arms) and adhesive performance.
  • To evaluate the *in vitro* cytotoxicity and *in vivo* biocompatibility of these novel adhesives.

Main Methods:

  • Synthesis of multiarmed polycaprolactones with varying numbers of functionalized arms (NHS, CHO, NCO).
  • Assessment of adhesive strength using rat skin models.
  • Evaluation of *in vitro* cytotoxicity using standard cell-based assays.
  • Assessment of *in vivo* biocompatibility through animal studies.

Main Results:

  • Adhesive strength increased with the number of functionalized arms, with 8-arm PCL demonstrating significantly higher adhesion (up to 11.2 N cm-2) compared to 2-arm PCL (2.3 N cm-2).
  • Both aldehyde (CHO) and isocyanate (NCO) functionalized 8-arm PCL exhibited suitable adhesive properties.
  • All synthesized multiarmed PCLs showed minimal *in vitro* cytotoxicity and good *in vivo* biocompatibility.

Conclusions:

  • Multiarmed polycaprolactones represent a promising class of biocompatible tissue adhesives.
  • The number of functionalized arms is a key factor in determining adhesive strength.
  • These PCL-based adhesives offer a potential alternative to existing surgical glues with an improved balance of strength and safety.