Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

4.2K
Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds...
4.2K
Aging01:26

Aging

515
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
515
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

3.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
3.1K
Mitochondria01:37

Mitochondria

19.3K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
19.3K
Cellular Differentiation00:57

Cellular Differentiation

4.9K
How does a complex organism such as a human develop from a single cell? It all starts from a single fertilized egg which gives rise to a vast array of cell types, such as nerve cells, muscle cells, and epithelial cells that characterize the adult? Throughout development and adulthood, cellular differentiation leads cells to assume their final morphology and physiology. Differentiation is the process by which unspecialized cells become specialized to carry out distinct functions.
A zygote is a...
4.9K
Telomeres and Telomerase02:41

Telomeres and Telomerase

6.7K
6.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concomitant Assessment of Oral and Gastric Microbiota Composition in Autoimmune Gastritis Patients: A Case-Control Study.

Microorganisms·2026
Same author

Identifying biomarkers of deafness-induced cerebral plasticity using MRI.

NeuroImage·2026
Same author

Helicobacter pylori multiplex serology in patients with autoimmune atrophic gastritis negative for Helicobacter pylori at histology: A case-control study.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026
Same author

Tenascin-C from the tissue microenvironment promotes muscle stem cell maintenance and function through Annexin A2.

Communications biology·2025
Same author

Modulation of the JAK2-STAT3 pathway promotes expansion and maturation of human iPSC-derived myogenic progenitor cells.

Stem cell reports·2025
Same author

Regional gray matter thickness correlations of the hearing and deaf feline brains.

Neuroimage. Reports·2025
Same journal

Inflammation Impairs Poststroke Recovery by Disrupting Iron Homeostasis in Brain.

Antioxidants & redox signaling·2026
Same journal

Histone Lactylation Links Glycolysis to Ferroptosis in Diabetic Cataract.

Antioxidants & redox signaling·2026
Same journal

Insights into the Multifaceted Roles of 3-Mercaptopyruvate Sulfurtransferase in Liver Diseases.

Antioxidants & redox signaling·2026
Same journal

NINJ1 Aggravates Doxorubicin-Induced Cardiotoxicity by Suppressing AMPK-Mediated HIF-1α Deubiquitination.

Antioxidants & redox signaling·2026
Same journal

<i>Corrigendum to:</i> Suppression of Cardiac Autophagy by Hyperinsulinemia in Insulin Receptor-Deficient Hearts Is Mediated by Insulin-Like Growth Factor Receptor Signaling.

Antioxidants & redox signaling·2026
Same journal

Sleeve Gastrectomy Is Associated with Improved Systemic Redox Homeostasis in T2DM Through Ghrelin-GHSR Attenuation, POMC Neuronal Modulation, and CD4<sup>+</sup> T Cell Metabolic Reprogramming.

Antioxidants & redox signaling·2026
See all related articles

Related Experiment Video

Updated: Dec 25, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.8K

From Development to Aging: The Path to Cellular Senescence.

Alessandra Sacco1, Laura Belloni2, Lucia Latella3,4

  • 1Development, Aging and Regeneration Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA.

Antioxidants & Redox Signaling
|April 2, 2020
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a state of irreversible cell cycle arrest, is complex and heterogeneous. Understanding senescent cell diversity is key to developing targeted therapies for aging and disease.

Keywords:
agingdevelopmentmuscle regenerationplasticitysenescence

More Related Videos

SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.9K
Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.7K

Related Experiment Videos

Last Updated: Dec 25, 2025

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

17.8K
SA-&#946;-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs
07:39

SA-β-Galactosidase-Based Screening Assay for the Identification of Senotherapeutic Drugs

Published on: June 28, 2019

24.9K
Techniques to Induce and Quantify Cellular Senescence
06:51

Techniques to Induce and Quantify Cellular Senescence

Published on: May 1, 2017

34.7K

Area of Science:

  • Cellular Biology
  • Aging Research
  • Molecular Medicine

Background:

  • Senescence is a cellular state characterized by cell cycle arrest, altered morphology, and the senescence-associated secretory phenotype (SASP).
  • Senescent cells accumulate in various physiological and pathological conditions, including development, tissue repair, aging, and cancer.
  • Evidence suggests senescent cells in vivo are heterogeneous, influenced by cell-autonomous pathways and microenvironmental factors.

Purpose of the Study:

  • To review the diverse roles of senescence in different biological contexts, highlighting both beneficial and detrimental outcomes.
  • To emphasize the heterogeneity of senescent cells and the need to characterize their specific molecular profiles and secretomes.
  • To discuss future research directions for understanding senescent cell heterogeneity and its therapeutic implications.

Main Methods:

  • Literature review of studies on cellular senescence.
  • Analysis of evidence regarding the heterogeneity of senescent cells in vivo.
  • Discussion of the implications of senescence heterogeneity for therapeutic strategies.

Main Results:

  • Senescence plays critical roles in both beneficial processes (e.g., development, repair) and detrimental conditions (e.g., aging, cancer).
  • Senescent cell populations are inherently heterogeneous due to varying activation pathways and microenvironmental influences.
  • Characterizing the molecular profiles and secretomes of distinct senescent cell types is crucial.

Conclusions:

  • The heterogeneity of senescent cells presents a challenge and an opportunity for targeted interventions.
  • Further research into senescent cell diversity will enable precise mapping of cellular trajectories.
  • Understanding senescence heterogeneity is vital for advancing senolytic therapies and improving health span.