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IL-9 and IL-9-producing cells in tumor immunity
Jie Wan1, Yinqiu Wu1, Xiaoyun Ji1
1Department of Immunology, Jiangsu University, Zhenjiang, 212013, China.
Cell Communication and Signaling : CCS
|April 2, 2020
Summary
Interleukin-9 (IL-9) is a cytokine with a dual role in cancer. While Th9 cell-derived IL-9 shows antitumor effects, other IL-9 sources may impact tumor immunity, influencing tumorigenesis and treatment.
Area of Science:
- Immunology
- Oncology
- Cell Biology
Background:
- Interleukin-9 (IL-9) is a cytokine belonging to the IL-2Rγc chain family.
- IL-9 was initially recognized for its role in T cell and mast cell growth.
- Historically, IL-9 has been linked to allergic, autoimmune, and parasitic diseases.
Purpose of the Study:
- To review the recent literature on IL-9's multifaceted role in cancer immunity.
- To explore the contributions of various IL-9-producing cells to tumor development and immune response.
- To provide insights into IL-9's potential as a therapeutic target in cancer treatment.
Main Methods:
- Literature review of recent studies on IL-9 and tumor immunity.
- Analysis of the roles of T-helper 9 (Th9) cells, CD8+ T (Tc9) cells, mast cells, and Vδ2 T cells in cancer.
- Synthesis of findings regarding IL-9's impact on tumorigenesis and anti-tumor responses.
Main Results:
- IL-9 exhibits a "double-edged sword" effect in cancer development.
- T-helper 9 (Th9) cell-derived IL-9 has demonstrated significant anti-tumor activity in solid tumors.
- Emerging research highlights the roles of IL-9 from Tc9 cells, mast cells, and Vδ2 T cells in tumor immunity.
Conclusions:
- IL-9's role in cancer immunity is complex and cell-type dependent.
- Understanding the specific contributions of different IL-9-producing cells is crucial for cancer therapy.
- Further research into IL-9 pathways may offer novel strategies for cancer treatment.
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