Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

215
Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
215
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

356
Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
356
Chronic Kidney Disease III: Interprofessional Care01:28

Chronic Kidney Disease III: Interprofessional Care

275
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
275
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

263
Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
263
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

357
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
357
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration01:28

Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration

119
Glomerular filtration rate (GFR) can be estimated from serum creatinine using the modification of diet in renal disease (MDRD) formula or the chronic kidney disease–epidemiology collaboration (CKD–EPI) equation. Both methods are widely used in clinical practice to assess kidney function and guide treatment decisions.The MDRD equation does not require weight or height measurements and is normalized to the body surface area of 1.73 m², considered the average adult surface area.
119

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Primary hyperoxaluria type 1-current practice in the siRNA era: an ERA Genes & Kidney Working Group survey.

Clinical kidney journal·2026
Same author

A Lethal Progressive Neuroinflammation Disguised as MOGAD Revealing a Final Diagnosis of Griscelli Syndrome.

Annals of clinical and translational neurology·2026
Same author

Virtual reality training for cognitive impairment in adults treated with haemodialysis (VIRTUAL): protocol for a multicentre, randomised, open-label feasibility trial.

BMJ open·2026
Same author

First-in-human to proof-of-concept: why experimental medicine studies remain essential in human physiology and drug development.

Pflugers Archiv : European journal of physiology·2026
Same author

Compound Heterozygous <i>COA7</i> Variants Presenting With Childhood-Onset Axonal Neuropathy in 2 Siblings.

Neurology. Genetics·2026
Same author

The evolving field of nephrology: what comes next? A report from the European Renal Association Scientific Advisory Board.

Clinical kidney journal·2026

Related Experiment Video

Updated: Dec 25, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K

How to assess kidney function in oncology patients.

Jolanta Malyszko1, Michael W Lee2, Giovambattista Capasso3

  • 1Department of Nephrology, Dialysis and Internal Medicine, Warsaw Medical University, Warsaw, Poland.

Kidney International
|April 2, 2020
PubMed
Summary

Accurate kidney function assessment is crucial for cancer patients to optimize treatment and avoid adverse effects. Further research is needed to validate current methods and explore new technologies for monitoring kidney health during cancer therapy.

Keywords:
biomarkersglomerular filtration ratekidney functiononcology

More Related Videos

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.8K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.4K

Related Experiment Videos

Last Updated: Dec 25, 2025

Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.6K
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
09:02

A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

Published on: February 2, 2021

4.8K
Assessment of Kidney Function in Mouse Models of Glomerular Disease
09:16

Assessment of Kidney Function in Mouse Models of Glomerular Disease

Published on: June 30, 2018

18.4K

Area of Science:

  • Nephrology
  • Oncology
  • Pharmacology

Background:

  • Kidney function assessment is vital for cancer patient survival risk, drug dosing, and clinical trial eligibility.
  • Inaccurate kidney function estimation can lead to suboptimal treatment, toxicity, or treatment failure.
  • Current methods for evaluating kidney function in oncology require further investigation for various cancer therapies.

Purpose of the Study:

  • To highlight the importance of accurate kidney function assessment in oncology.
  • To discuss the limitations of current estimation formulas for glomerular filtration rate and creatinine clearance.
  • To emphasize the need for comprehensive kidney function evaluation beyond filtration rate, including tubular and vascular aspects.

Main Methods:

  • Review of current practices in kidney function assessment for oncology patients.
  • Discussion of the impact of overestimation and underestimation of kidney function on treatment outcomes.
  • Exploration of the role of urinalysis and kidney imaging in therapeutic decision-making.
  • Consideration of novel technologies like kidney-on-a-chip systems.

Main Results:

  • Current formulas for estimating kidney function may not be universally applicable to all cancer patients and therapies.
  • Over/underestimation of kidney function can significantly impact chemotherapy efficacy and patient safety.
  • Comprehensive assessment involving filtration, tubular, and vascular parameters is necessary.
  • New technologies show promise but require further validation for clinical use in oncology.

Conclusions:

  • Accurate kidney function assessment is fundamental for personalized cancer treatment and improved patient outcomes.
  • There is a critical need for validated methods to assess kidney function in the context of evolving cancer therapies.
  • Integrating advanced diagnostic tools and considering broader aspects of kidney health are essential for managing oncology patients.