Related Experiment Video
Updated: Dec 25, 2025

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
Published on: July 2, 2021
Transient Familial Factor V Leiden-Linked Hip Osteoporosis
D Serrano-Toledano1, M Del Río-Arteaga2, J Ribera-Zabalbeascoa3
1Unidad de Cadera y Rodilla, Hospital Viamed Santa Ángela de la Cruz, Sevilla, España; Hospital Comarcal Básico de Riotinto, Huelva, España.
Introduction:
Transient osteoporosis of the hip (THO) is a rare disease of unknown pathogenesis that has traditionally been considered an early and reversible stage of avascular necrosis (AN). Thrombophilia or familial hypofibrinolysis is considered a risk factor for the development of AN and THO. Factor V Leiden is one of the most common hereditary hypercoagulability disorders.
Clinical Cases:
Case series study. The development and course of 3THO cases in 3siblings (two males and one female) aged between 40 and 43 years are described consecutively. Clinical and nuclear magnetic resonance imaging (MRI) studies confirmed the diagnosis of THO and ruled out the presence of AN. The G1691A mutation of factor v Leiden was positive in all cases. The clinical and radiological outcome was favourable, with healing without sequelae and disappearance of bone oedema on control MRI at 6 months in all cases.
Discussion:
The results of this study support the ischaemic aetiology and establish HTO as an early and reversable stage of hip AN. Factor V Leiden causes a state of hypercoagulability and hypofibrinolysis that encourages the development of THO due to ischaemic causes.
Conclusions:
This study outlines the first familiar description of factor v Leiden-linked THO.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bones of the Lower Limb: Femur and Patella
Translation
Translation Produces the Building Blocks of Life
Proteins are...
Osteoclasts in Bone Remodeling
Point and Frameshift Mutations
Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

